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MMR side-effects

发布时间:2019-03-07 09:12:02来源:未知点击:

By Claire Ainsworth MMR vaccination of children can occasionally cause a bleeding disorder, resulting a rash-like reaction, a new study in Britain has confirmed. Doctors have known of this side-effect for over 10 years, but the new work provides a more accurate assessment of the risk of developing it. In the wake of much public concern in the UK about suggested links between MMR and autism, the research also provides the opportunity to highlight the advantages and disadvantages of the combined vaccination for measles, mumps and rubella. The rash results from the bleeding disorder idiopathic thrombocytopenic purpura (ITP). It is a rare and mild side-effect of vaccination, stresses Brent Taylor of the Royal Free and University Medical School in London, who was part of the study team. “The benefits of vaccination enormously outweigh the risk,” he says. ITP is caused by a shortage of platelets in the blood. This leads to mild bleeding beneath the skin, giving a rash of small, bruise-like spots. ITP is known to be a side-effect of live viral vaccines such as MMR, and although unpleasant, it is rarely dangerous. Most of the children affected have a rash for less than two weeks, and then make a complete recovery by themselves. Less than five per cent of ITP patients develop chronic problems requiring treatment. Furthermore, the majority of ITP cases are caused by viral infections such as measles or rubella. “The children who develop ITP after vaccination tend to have milder symptoms than those developing it after viral infection,” says Elizabeth Miller, of the Public Health Laboratory Service, who led the research team. Miller and her colleagues studied hospital admissions for children with ITP, and estimate that one in every 22,300 MMR vaccinations would result in hospital admission for the condition. They also concluded that the shots caused two thirds of ITP cases that occurred within six weeks of MMR vaccination. But children who had already had non-vaccine-related ITP had no increased risk of developing the condition again. Although some children were admitted to hospital for ITP, Miller says the effects are mild, especially compared with the serious consequences of measles, mumps or rubella infection. ” We are very open about the effects of MMR,” adds Taylor. “There is no conspiracy to suppress information on side-effects.” More at: Archives of Disease in Childhood (vol 84,